
The Substance
A fading Hollywood icon desperate to reclaim her spotlight ingests a mysterious serum that splits her into two bodies, forcing her to alternate consciousness every week while racing against a deadly countdown to keep both selves alive and her career thriving.
“Have you ever dreamt of a better version of yourself?”
Synopsis
A fading celebrity turns to a black market drug, a cell-replicating substance that temporarily produces a younger, improved version of herself.
Credits
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How many hands made this film
The scale of the collaboration
A crew of 128+ credited
Why a floor?
This is a minimum, not a total. We only count the credits we’ve captured so far, and coverage is uneven — a blockbuster might show a few hundred names while another of the same size shows a couple dozen. The real crews all ran into the thousands. The number here only grows as full credits are enriched — so we frame it as a floor, never a headcount.
Craft leads on file
Edited by Jerome EltabetShot by Benjamin KracunScored by RaffertieDesigned by Stanislas Reydellet
Box Office
2024 · Box office
💰 Box-office hit — grossed 4.4× its budget
Why 2.5×?
Cinemas keep roughly half of every ticket sold, and a wide release’s marketing often costs about as much again as the film — so a movie needs to gross around 2.5× its production budget just to break even theatrically. It’s a rule of thumb, not the studio’s ledger (home video and streaming come later).
Worldwide gross
$77.3M
US & Canada: $17.6M — 23% of worldwide · International: $59.7M (77%)
Opening weekend: $3.2M — 18% of its US run.
Opening week (7-day): $5.1M — 29% of its US & Canada run.
Peak 1,949 theaters
Full synopsis
Also known as
- La Sustanciaes
Community tags
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Cast & Crew
128 unique people credited
Top billed cast
Demi Moore
as Elisabeth
Margaret Qualley
as Sue
Dennis Quaid
as Harvey
Edward Hamilton Clark
as Fred
Gore Abrams
as Oliver
Oscar Lesage
as Troy
Christian Erickson
as Man at Diner
Robin Greer
as Male Nurse
Tom Morton
as Doctor
Hugo Diego Garcia
as Diego - Boyfriend
Daniel Knight
as Casting Director
Jonathon Carley
as Assistant Casting Director
Supporting cast
108Jiselle Henderkott
as Girl Auditioning / New Year's Eve Show Dancer
Akil Wingate
as TV Host
Vincent Colombe
as Man in Suit #1 - Harvey's Office
Billy Bentley
as Man in Suit #2
Lennard Ridsdale
as Man in Suit #3
Jordan Ford Silver
as Assistant Director - Pump It Up Show
Oscar Salem
as 2nd Assistant Director - Pump It Up Show
Viviane Bossina
as Sue's Assistant
Matthew Luret
as Floor Runner
Jana Bittnerova
as Maria
Olivier Raynal
as Alan - 2nd Agent
Tiffany Hofstetter
as Stylist
Nicolas Royer
as Guy in the Elevator
Nathan Rippy
as Assistant Director - New Year's Eve Show
Manon Arizmendi
as Little Girl - New Year's Eve Show
Virginie Kotlinski
as Mother - New Year's Eve Show
Brett Gillen
as Director of Photography - New Year's Eve Show
Charlotte Marquardt
as Screaming Woman
Lea Hengl
as Screaming Woman
Gaelle Raymond
as Screaming Woman
Claire Lemaire
as Screaming Woman
Lila Boughoufala
as Screaming Woman
Aurelien Lorgnier
as Screaming Man
Ivan Sellier
as Screaming Man
Philip Schurer
as Screaming Man
Christian Bourmier
as Shareholder
Martin Graham
as Shareholder
Christian Bordeleau
as Shareholder
Patrick Hamel
as Shareholder
Didier Dhondt
as Shareholder
Jacques Yves Dorges
as Shareholder
Jean Claude Matthey
as Shareholder
Olivier Jarcin
as Shareholder
Jean Luc Magneron
as Shareholder
Charlotte Murray
as Allison - Diner Waitress
Aaron Kahn
as Greeting Person
Gabriela Arnon
as Greeting Person
Nancy Josephson Lahoussine
as Greeting Person
Andrew Eldridge
as Greeting Person
Denise Powers
as Greeting Person
Bryan Jones
as Greeting Person
Adam Carage
as Happy Birthday Person
Maria Mcclurg
as Happy Birthday Person
Andrew Desmond
as Happy Birthday Person
Rebecca Lafont
as Happy Birthday Person
Laura Puech
as Isabella
Ryan Chidester
as Stagehand
Cecile Vogt
as Elisabeth (Young) - Walk of Fame / Pump It Up Show Dancer
Yannick Guerin
as Clumsy Burger Guy - Walk of Fame
Jean Miel
as Worker Walk of Fame
Paul Descoings
as Worker Walk of Fame
Benoit Leveque
as Worker Walk of Fame
Arthur Molinet
as Cocktail Bartender
Manon Sachot
as Cocktail Lounge Couple
Bastien Jorelle
as Cocktail Lounge Couple
Kelly Hoarau
as Female Assistant - Towel
Michel Juskiewicz
as George - Harvey's Friend
Louise Greggory
as Restaurant Waitress
Christophe Sartirano
as Guy Looking at Sue
Florent Torres
as Guy Looking at Sue
Romain Caldeira
as Billboard Technician
Barthelemy Thomas
as Billboard Technician
Axel Baille
as Photographer
Ashley Lambert
as Additional Voices (voice)
Ranjani Brow
as Additional Voices (voice)
Chase Fein
as Additional Voices (voice)
Shane Sweet
as Additional Voices (voice)
William Calvert
as Additional Voices (voice)
Michael Corbett
as Additional Voices (voice)
Stephen Apostolina
as Additional Voices (voice)
Yann Bean
as The Substance (voice)
Audjyan Alcide
as Pump It Up Show Dancer
Jonathan Jenvrin
as Pump It Up Show Dancer
Mimi Maury
as Pump It Up Show Dancer
Amelye Solange
as Pump It Up Show Dancer
Kevin Table
as Pump It Up Show Dancer
Laura Boera
as Sparkle Your Life Show Dancer
Cissy Duc
as Sparkle Your Life Show Dancer
Sophie Mercier
as Sparkle Your Life Show Dancer
Marie Valton
as Sparkle Your Life Show Dancer
Katrina Budzynski
as New Year's Eve Show Dancer
Alicia Maury
as New Year's Eve Show Dancer
Megane Adamik
as New Year's Eve Show Dancer
Annalisa Pagnotta
as New Year's Eve Show Dancer
Maelle Dantigny
as New Year's Eve Show Dancer
Aleksandra Kedzierska Fontaine
as New Year's Eve Show Dancer
Pauline Sagetat
as New Year's Eve Show Dancer
Agustina Fitzsimons
as New Year's Eve Show Dancer
Elena Shcheglova
as New Year's Eve Show Dancer
Eve Marchant
as New Year's Eve Show Dancer
Lola Donati
as New Year's Eve Show Dancer
Kate Matthews
as New Year's Eve Show Dancer
Ophelie Jonard
as New Year's Eve Show Dancer
Pauline Richard
as New Year's Eve Show Dancer
Laureen Cappelliez
as New Year's Eve Show Dancer
Daria Panchenko
as New Year's Eve Show Dancer
Delphine Beaulieu
as New Year's Eve Show Dancer
Victoria Brun
as New Year's Eve Show Dancer
Cara Chapman
as New Year's Eve Show Dancer
Katharine Matthews
as New Year's Eve Show Dancer
Alexandra Faget
as New Year's Eve Show Dancer
Clemence Juville
as New Year's Eve Show Dancer
Margot L Entete
as New Year's Eve Show Dancer
Hillary Sukhonos
as New Year's Eve Show Dancer
Matthew Geczy
as Bob Haswell (uncredited)
Namory Bakayoko
as Silhouette (uncredited)
Gregory Defleur
as Happy Birthday Person (uncredited)
Coralie Fargeat
as (uncredited)
Directors
1Writers
1Producers
3Other crew
7Parents Guide
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Trailers
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Official Trailer
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