Maniac
Two disillusioned strangers enroll in a mysterious drug trial promising to erase their deepest flaws, only to discover the experiment spirals into a mind‑bending nightmare that threatens their sanity and reality itself.
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Two strangers are drawn to a mysterious pharmaceutical trial that promises, with no complications or side effects, to permanently solve all of their problems. Things do not go as planned.
Seasons & Episodes
Season 110 episodes · premiered Sep 21, 2018
- 1.01The Chosen One!Sep 21, 2018Rate
Owen Milgrim, a member of a wealthy family and diagnosed with schizophrenia, struggles with his place within the clan after being fired from his job. He joins an experimental drug trial in search of a solution to his mental health challenges.
- 1.02WindmillsSep 21, 2018Rate
Annie, struggling with addiction, attempts to quit after her supply of pills is stolen, but she resorts to manipulation to gain entry into the Neberdine research study.
- 1.03Having a DaySep 21, 2018Rate
Muramoto detects inconsistencies in Annie and Owen's work and confronts Owen, prompting him to recount a traumatic memory from his past—his brother's engagement party.
- 1.04Furs by SebastianSep 21, 2018Rate
Annie and Owen take the B pill and are transported to 1980s Long Island, where they become involved in an unusual adventure that includes a lemur.
- 1.05Exactly Like YouSep 21, 2018Rate
Arlie and Ollie, a pair of con artists in 1940s New England, attend a séance at the enigmatic Neberdine mansion in hopes of exposing the supernatural claims as a fraud.
- 1.06Larger Structural IssuesSep 21, 2018Rate
Azumi reveals the complications with the study to James and encourages him to reconnect with his mother, a respected therapist, in hopes of gaining perspective.
- 1.07Ceci N'est Pas Une DrillSep 21, 2018Rate
Owen and Annie each take a C pill, severing their connection and sending them to separate worlds—Owen becomes part of a Mafia family, while Annie works as a medieval guide for an ailing elf princess.
- 1.08The Lake of the CloudsSep 21, 2018Rate
Annia and Ellia advance on their journey, while Owen faces increasing pressure from his mob-connected father to safeguard the family's interests. Meanwhile, Greta offers emotional support to Gertie, who is grieving.
- 1.09UtangattaSep 21, 2018Rate
Owen, a disgraced Icelandic intelligence officer, reunites with Annie, a CIA agent who assists him in navigating his crisis. Meanwhile, Greta urges James to take action to end an ongoing trial.
- 1.10Option CSep 21, 2018Rate
James and Azumi confront the CEO of Neberdine following the subjects' discharge. Meanwhile, Owen and Annie go their separate ways, only to be brought back together by a surprising news story.
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Cast & Crew
85 unique people credited
Top billed cast
Cahit Kasikcilar
as Riza
Emma Stone
as Annie Landsberg
Emel Emir
as Serpil
Jonah Hill
as Owen Milgrim
Fatma Pazvant
as Mother
Sonoya Mizuno
as Dr. Azumi Fujita
Mehmet Vanlioglu
as Kemal
Justin Theroux
as Dr. James K. Mantleray
Zehra Sozuguzel
as Emine
Sally Field
as Dr. Greta Mantleray
Erdal Parmaksizoglu
as Remzi
Kathleen Choe
as 3
Supporting cast
64Mesut Hakyemez
as Lokman
Danny Hoch
as 5
Ufuk Durmaz
as Boss
Allyce Beasley
as 11
James Monroe Iglehart
as Carl (8 Episodes)
Berat Demireger
as Nihat
Stephen Hill
as 7
Dai Ishiguro
as Head Control Tech (8 Episodes)
Cetin Altindal
as Sebo
Sejal Shah
as First Medical Tech (8 Episodes)
Aaralyn Anderson
as Belle Milgrim (5 Episodes) , Danielle Marino (1 Episode) , Australia (1 Episode)
Billy Magnussen
as Jed Milgrim (7 Episodes)
Gabriel Byrne
as Porter Milgrim (5 Episodes)
Jemima Kirke
as Adelaide (5 Episodes)
Julia Garner
as Ellie Landsberg (5 Episodes)
Nate Craig
as Phil (5 Episodes)
Alexandra Curran
as Holly Milgrim (5 Episodes)
Trudie Styler
as Angelica Milgrim (4 Episodes)
Christian Demarais
as Mike Milgrim (4 Episodes)
Cailin Loesch
as Lady of Arquesta (4 Episodes)
Hannah Loesch
as Lady of Arquesta (4 Episodes)
Geoffrey Cantor
as Frank (4 Episodes)
Rome Kanda
as Dr. Muramoto (4 Episodes)
Ramya Pratt
as Vicky / Green Hoodie Woman (3 Episodes)
Jacqueline Grabois
as Annie's Roommate (2 Episodes) , — (1 Episode)
Zach Shearon
as — (1 Episode) , Young Boy in a Truck (1 Episode) , Young Soldier (1 Episode)
Hank Azaria
as Hank Landsberg (voice) (3 Episodes)
Ariel Kavoussi
as Female Ad Buddy / Bianca Forsythe / Dragonfly (voice) (3 Episodes)
Selenis Leyva
as Patricia Lugo (3 Episodes)
Lev Gorn
as Sokolov (3 Episodes)
Josh Pais
as Andy (3 Episodes)
Grace Van Patten
as Olivia Meadows (3 Episodes)
Maho Honda
as Intake Tech (2 Episodes)
Lauren E Banks
as Prosecutor (1 Episode) , Winged Nymph (1 Episode)
Eric T Miller
as Daddy's Here Operator (1 Episode) , Douglas on the Radio (1 Episode)
Marlene Ginader
as Beth Sanders (2 Episodes)
Leo Fitzpatrick
as Lance (2 Episodes)
Jojo Gonzalez
as Agent Lopez (2 Episodes)
Maxine Prescott
as Mrs. Finkelstein (2 Episodes)
Joseph Sikora
as JC (2 Episodes)
David Fierro
as Ad Buddy (2 Episodes)
Jonathan Rentler
as — (2 Episodes)
Mike Masters
as — (2 Episodes)
Lindsey Blanchard
as Little Ellie (1 Episode)
Marcus Toji
as Calvin (1 Episode)
Rob Yang
as Matt Ming (1 Episode)
Ben Sinclair
as — (1 Episode)
Elaine Bromka
as — (1 Episode)
Rob Derosa
as — (1 Episode)
Jennifer Ikeda
as — (1 Episode)
Subhash Mandal
as — (1 Episode)
Tony Manna
as — (1 Episode)
Sean Meehan
as General Nathan Banner (1 Episode)
Louis Arcella
as Portuguese General (1 Episode)
Lukas Hassel
as Danish General (1 Episode)
Min Wen Huang
as — (1 Episode)
Olivia Whelan
as — (1 Episode)
Glenn Fleshler
as — (1 Episode)
Alexandra Henrikson
as — (1 Episode)
Alix Korey
as — (1 Episode)
Glenn Wein
as — (1 Episode)
Chris Ghaffari
as Julio (1 Episode)
Laura Marie Steigers
as Nurse (1 Episode)
Sissy Sheridan
as — (1 Episode)
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